Berlin has two major bus stations in Berlin: the Central Bus Station at Funkturm, also called ZOB Berlin, and the bus station at Berlin-Ostbahnhof. Both stations are served by national and international coaches every day.

The majority of national and international bus lines to and from Berlin arrive and depart at Berlin's Central Bus Station ZOB, the larger of the two international bus stations in the city. The ZOB is located in the district of Charlottenburg, opposite the International Congress Center (ICC) and the exhibition grounds.

The second major bus station is located at Ostbahnhof Station in the district of Friedrichshain, east of Alexanderplatz. From Ostbahnhof, Berlin's Central Station can be reached within ten minutes by taking the S-Bahn.